Faculty Collaboration Database

Neural and hormonal control of Brunner's gland secretion. Life Sci 1982 Feb 01;30(5):409-17

Date

02/01/1982

Pubmed ID

7038364

DOI

10.1016/0024-3205(82)90456-8

Scopus ID

2-s2.0-0020046107 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

For many years it has been speculated that the physiological function of Brunner's glands was to secrete mucus to protect the proximal duodenum from the corrosive effects of acidified gastric juice. However the control of Brunner's gland secretion remains an enigma. Some evidence exists which indicates both cholinergic and adrenergic innervation of these glands, but current consensus weighs heavily in favor of a hormonal stimulus for glandular secretion. This is based in part on evidence obtained from denervated Brunner's gland pouches following a feeding stimulus. a number of hormones and hormone-like substances have been investigated as possible mediators in this secretory response, however, no specificity was ever demonstrated. The inability to pinpoint a given substance as a common mediator can be attributed to the fact that most active agents employed also affect duodenal motility. We present evidence that Brunner's gland secretion can be observed to be a diphasic response. The initial, transient response is always observed in the presence of increased duodenal motility. The sustained response does not require duodenal motility and is probably hormonally mediated.

Author List

Lang IM, Tansy MF

Author

Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Brunner Glands
Cats
Dogs
Duodenum
Exocrine Glands
Gastric Juice
Gastrointestinal Hormones
Gastrointestinal Motility
Mucus
Parasympathetic Nervous System
Rabbits