Pulmonary denervation in the dog. J Appl Physiol Respir Environ Exerc Physiol 1983 Jun;54(6):1451-6
Date
06/01/1983Pubmed ID
6874467DOI
10.1152/jappl.1983.54.6.1451Scopus ID
2-s2.0-0020595224 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
To produce a chronically lung-denervated animal model, a single-stage surgical procedure was performed on five beagle dogs. A left thoracotomy allowed hilar stripping of the pulmonary contributions to the left vagus nerve and transection of the right vagal trunk. The criterion for denervation was defined as the absence of the Hering-Breuer reflex (HBR). The five denervated dogs (DD) as well as five control dogs (CD) were evaluated for presence of the HBR under pentobarbital sodium (Nembutal, 30 mg/kg) anesthesia. Between the 3rd and 8th wk postsurgery, the HBR was clearly abolished in the DD but present in the CD. By the 12th-14th wk postsurgery, the HBR was again present in the DD. This relatively uncomplicated surgical procedure effectively produced a lung-denervated animal model. However, reinnervation occurred relatively soon, thus demonstrating the importance of regular frequent evaluation of the HBR when using this and any other surgically produced pulmonary denervation model.
Author List
Clifford PS, Coon RL, von Colditz JH, Zuperku EJ, Kampine JPAuthor
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDenervation
Dogs
Lung
Reflex
Respiration
Time Factors
