Medical College of Wisconsin
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Corticosteroids in inflammatory bowel disease. A review. J Clin Gastroenterol 1987 Oct;9(5):529-35

Date

10/01/1987

Pubmed ID

3316373

DOI

10.1097/00004836-198710000-00008

Scopus ID

2-s2.0-0023243146 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Corticosteroids have been used for decades in the treatment of inflammatory bowel disease. Despite considerable information on the clinical response to corticosteroids in inflammatory bowel disease, much less is known concerning corticosteroids' effects on the underlying immunopathology of the disease. In this review, we discuss the known immunologic actions of corticosteroids: their effects on eicosanoid production and on modulating the humoral and cellular immune response. After reviewing the postulated immunological aberrations in inflammatory bowel disease, we speculate on the specific immunologic effects of corticosteroids in this disease.

Author List

Routes J, Claman HN

Author

John M. Routes MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Hormones
Colitis, Ulcerative
Crohn Disease
Humans
Immunity, Cellular
Leukocytes