Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors. J Cardiovasc Transl Res 2020 Jun;13(3):402-416
Date
04/08/2020Pubmed ID
32253744Pubmed Central ID
PMC8855704DOI
10.1007/s12265-020-09992-5Scopus ID
2-s2.0-85083402203 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Cancer therapies have been evolving from conventional chemotherapeutics to targeted agents. This has fulfilled the hope of greater efficacy but unfortunately not of greater safety. In fact, a broad spectrum of toxicities can be seen with targeted therapies, including cardiovascular toxicities. Among these, cardiomyopathy and heart failure have received greatest attention, given their profound implications for continuation of cancer therapies and cardiovascular morbidity and mortality. Prediction of risk has always posed a challenge and even more so with the newer targeted agents. The merits of accurate risk prediction, however, are very evident, e.g. facilitating treatment decisions even before the first dose is given. This is important for agents with a long half-life and high potential to induced life-threatening cardiac complications, such as myocarditis with immune checkpoint inhibitors. An opportunity to address these needs in the field of cardio-oncology is provided by the expanding repertoire of "-omics" and other tools in precision medicine and their integration in a systems biology approach. This may allow for new insights into patho-mechanisms and the creation of more precise and cost-effective risk prediction tools with the ultimate goals of improved therapy decisions and prevention of cardiovascular complications. Herein, we explore this topic as a future approach to translating the complexity of cardio-oncology to the reality of patient care.
Author List
Brown SA, Ray JC, Herrmann JMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents, Immunological
Cancer Survivors
Cardiology
Cardiotoxicity
Heart Diseases
Humans
Medical Oncology
Molecular Targeted Therapy
Neoplasms
Precision Medicine
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Risk Assessment
Risk Factors
Systems Biology
