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Platinum (II) Porphyrin-Containing Thermoresponsive Poly(N-isopropylacrylamide) Copolymer as Fluorescence Dual Oxygen and Temperature Sensor. Sens Actuators B Chem 2011 Nov 28;159(1):135-141

Date

09/20/2011

Pubmed ID

21927540

Pubmed Central ID

PMC3171833

DOI

10.1016/j.snb.2011.06.061

Scopus ID

2-s2.0-80052314241

Abstract

A random copolymer, poly(NIPAAm-co-PtPorphyrin), consisting of N-isopropylacrylamide (NIPAAm) and platinum (II) porphyrin units, behaves as an optical dual sensor for oxygen and temperature. The dual sensor is designed by incorporating an oxygen-sensitive platinum (II) porphyrin (M1) into a temperature-sensitive polymer (PNIPAAm). The polymer exhibited low critical solution temperature (LCST) property at 31.5 °C. This LCST affected the polymer's aggregation status, which in turn affected the nanostructures, fluorescence intensities, and responses to dissolved oxygen. This enables the polymer to functionalize as a dual temperature and dissolved oxygen sensor. Oxygen response of the platinum (II) porphyrin probes in the polymer followed a two-site Stern-Volmer model, indicating the nonuniform distribution of the probes. The copolymer was used to preliminarily monitor the oxygen consumption of Escherichia coli (E. coli) bacteria. The results indicate a potential application of the polymer in biological fields.

Author List

Zhou X, Su F, Tian Y, Johnson RH, Meldrum DR

Author

Roger H. Johnson PhD Associate Professor in the Biophysics department at Medical College of Wisconsin