Medical College of Wisconsin
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Feldkamp and circle-and-line cone-beam reconstruction for 3D micro-CT of vascular networks. Phys Med Biol 1998 Apr;43(4):929-40

Date

05/08/1998

Pubmed ID

9572516

DOI

10.1088/0031-9155/43/4/020

Scopus ID

2-s2.0-0031972279   53 Citations

Abstract

Detailed morphometric knowledge of the microvascular network is needed for studies relating structure to haemodynamic function in organs like the lung. Clinical volumetric CT is limited to millimetre-order spatial resolution. Since evidence suggests that small arterioles (50 to 300 micrometres) dominate pulmonary haemodynamics, we built a micro-CT scanner, capable of imaging excised lungs in 3D with 100 microm resolution, for basic physiology research. The scanner incorporates a micro-focal (3 microm) x-ray source, an xyz theta stage and a CCD-coupled image intensifier detector. We imaged phantoms and contrast-enhanced rat lungs, reconstructing the data with either the Feldkamp or the circle-and-line cone-beam reconstruction algorithm. We present reconstructions using 180 views over 360 degrees for the circular trajectory, augmented with views from a linear scan for the circle-and-line algorithm. Especially for platelike features perpendicular to the rotation axis and remote from the midplane, the circle-and-line algorithm produces superior reconstructions compared with Feldkamp's algorithm. We conclude that the use of nonplanar source trajectories to perform micro-CT on contrast-enhanced, excised lungs can provide data useful for morphometric analysis of vascular trees, currently down to the 130 microm level.

Author List

Johnson RH, Hu H, Haworth ST, Cho PS, Dawson CA, Linehan JH

Author

Roger H. Johnson PhD Associate Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Algorithms
Animals
Equipment Design
Humans
Image Processing, Computer-Assisted
Lung
Microcirculation
Miniaturization
Models, Anatomic
Models, Theoretical
Phantoms, Imaging
Pulmonary Circulation
Rats
Tomography, X-Ray Computed