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Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations. Ann N Y Acad Sci 2020 May 13

Date

05/14/2020

Pubmed ID

32401362

DOI

10.1111/nyas.14366

Abstract

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.

Author List

Klimara MJ, Randall DR, Allen J, Figueredo E, Johnston N

Author

Nikki Johnston PhD Associate Professor in the Otolaryngology department at Medical College of Wisconsin




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