Medical College of Wisconsin
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Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations. Ann N Y Acad Sci 2020 May 13



Pubmed ID





Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.

Author List

Klimara MJ, Randall DR, Allen J, Figueredo E, Johnston N


Nikki Johnston PhD Associate Professor in the Otolaryngology department at Medical College of Wisconsin

jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280