Correspondence of low mean shear and high harmonic content in the porcine iliac arteries. J Biomech Eng 2006 Dec;128(6):852-6
Date
12/13/2006Pubmed ID
17154685DOI
10.1115/1.2354211Scopus ID
2-s2.0-33846443970 29 CitationsAbstract
BACKGROUND: Temporal variations in shear stress have been suggested to affect endothelial cell biology. To better quantify the range of dynamic shear forces that occur in vivo, the frequency content of shear variations that occur naturally over a cardiac cycle in the iliac arteries was determined.
METHOD OF APPROACH: Computational fluid dynamic calculations were performed in six iliac arteries from three juvenile swine. Fourier analysis of the time-varying shear stress computed at the arterial wall was performed to determine the prevalence of shear forces occurring at higher frequencies in these arteries.
RESULTS: While most of each artery experienced shear forces predominantly at the frequency of the heart rate, the frequency spectra at certain regions were dominated by shear forces at higher frequencies. Regions whose frequency spectra were dominated by higher harmonics generally experienced lower mean shear stress. The negative correlation between shear and dominant harmonic was significant (p=0.002).
CONCLUSIONS: Since lesion development typically occurs in regions experiencing low time-average shear stress, this result suggests that the frequency content of the shear exposure may also be a contributing factor in lesion development. A better understanding of the vascular response to shear components of different frequencies might help rationalize the notion of "disturbed flow" as a hemodynamic entity.
Author List
Himburg HA, Friedman MHAuthor
Heather A. Himburg PhD Associate Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiological Clocks
Blood Flow Velocity
Blood Pressure
Elasticity
Heart Rate
Iliac Artery
In Vitro Techniques
Models, Cardiovascular
Pulsatile Flow
Shear Strength
Swine
