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Thrombophilia and fetal loss: Lessons from gene targeting in mice. Thromb Res 2009;123 Suppl 2:S79-84

Date

02/17/2009

Pubmed ID

19217483

DOI

10.1016/S0049-3848(09)70017-9

Scopus ID

2-s2.0-65549169814 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Inherited thrombophilia is recognized as one of the causes of recurrent fetal loss. Yet, the risk of fetal loss in women with thrombophilia is far from absolute. Other risk modifiers are clearly involved, but remain to be identified. The mechanism that translates maternal thrombophilia into pregnancy disorder is also not understood. Genetically engineered mice have led to the development of new insights into the etiology and pathogenesis of thrombophilia-associated fetal loss. These insights are the focus of this review.

Author List

Sood R

Author

Rashmi Sood PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Animals, Genetically Modified
Disease Models, Animal
Factor V
Female
Fetal Death
Humans
Mice
Mice, Knockout
Pregnancy
Pregnancy Complications, Hematologic
Thrombophilia