Faculty Collaboration Database

[Whole cell recording of sodium, potassium and calcium currents of cultured neonatal rat sympathetic neurons]. Sheng Li Xue Bao 1995 Oct;47(5):441-7

Date

10/01/1995

Pubmed ID

8711507

Scopus ID

2-s2.0-1542470835 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Na, K and Ca currents and other electrophysiological characteristics of cultured neonatal rat superior cervical sympathetic neurons were studied using whole cell clamp technique. The mean passive and active membrane properties measured are as follows: resting membrane potential, -51 +/- 6 mV; input resistance, 1432 +/- 389 M omega; time constant, 130 +/- 32 ms; amplitude of action potential, 96 +/- 10 mV; overshoot, 42 +/- 6 mV. Na, K and Ca currents were isolated upon pharmacological manipulations. The predominant type of K current was a noninactivating delayed rectifier. Voltage-clamp studies also showed the presence of a high voltage-activated sustained inward Ca current, while low voltage could not elicit any transient Ca current.

Author List

He XP, Liu QS, Xie ZP, Liu CG

Author

Qing-song Liu PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Animals, Newborn
Calcium Channels
Cells, Cultured
Membrane Potentials
Neurons
Patch-Clamp Techniques
Potassium Channels
Rats
Rats, Wistar
Sodium Channels
Superior Cervical Ganglion