Two-point Dixon technique provides robust fat suppression for multi-mouse imaging. J Magn Reson Imaging 2010 Feb;31(2):510-4
Date
01/26/2010Pubmed ID
20099366Pubmed Central ID
PMC2903873DOI
10.1002/jmri.22060Scopus ID
2-s2.0-75749152985 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
PURPOSE: To determine whether Dixon-based fat separation techniques can provide more robust removal of lipid signals from multiple-mouse magnetic resonance imaging (MRI)-acquired images than conventional frequency selective chemical saturation techniques.
MATERIALS AND METHODS: A two-point Dixon technique was implemented using a RARE-based pulse sequence and techniques for multivolume fat suppression were evaluated using a 4-element array of volume resonators at 4.7 T. Images were acquired of both phantoms and mice.
RESULTS: Fat saturation was achieved on all four channels of the multiple mouse acquisition with the Dixon technique, while failures of fat saturation were found with chemical saturation techniques.
CONCLUSION: This proof of concept study found that Dixon fat separation provided more reliable and homogenous fat suppression than chemical saturation in phantoms and in vivo.
Author List
Ragan DK, Bankson JAAuthor
Dustin K. Ragan PhD Assistant Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adipose TissueAlgorithms
Animals
Feasibility Studies
Humans
Image Enhancement
Magnetic Resonance Imaging
Mice
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
