Cytokines, JAK-STAT Signaling and Radiation-Induced DNA Repair in Solid Tumors: Novel Opportunities for Radiation Therapy. Int J Biochem Cell Biol 2020 Oct;127:105827
Date
08/22/2020Pubmed ID
32822847Pubmed Central ID
PMC8638530DOI
10.1016/j.biocel.2020.105827Scopus ID
2-s2.0-85090734995 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
A number of solid tumors are treated with radiation therapy (RT) as a curative modality. At the same time, for certain types of cancers the applicable doses of RT are not high enough to result in a successful eradication of cancer cells. This is often caused by limited pharmacological tools and strategies to selectively sensitize tumors to RT while simultaneously sparing normal tissues from RT. We present an outline of a novel strategy for RT sensitization of solid tumors utilizing Jak inhibitors. Here, recently published pre-clinical data are reviewed which demonstrate the promising role of Jak inhibition in sensitization of tumors to RT. A wide number of currently approved Jak inhibitors for non-malignant conditions are summarized including Jak inhibitors currently in clinical development. Finally, intersection between Jak/Stat and the levels of serum cytokines are presented and discussed as they relate to susceptibility to RT.
Author List
Hall WA, Sabharwal L, Udhane V, Maranto C, Nevalainen MTAuthor
William Adrian Hall MD Professor in the Radiation Oncology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Clinical Trials as Topic
Cytokines
DNA Repair
Humans
Janus Kinases
Neoplasms
Protein Kinase Inhibitors
STAT Transcription Factors
Signal Transduction
