State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry. Arch Pathol Lab Med 2008 May;132(5):838-46
Date
05/10/2008Pubmed ID
18466033DOI
10.5858/2008-132-838-SOTAITScopus ID
2-s2.0-43049106810 (requires institutional sign-in at Scopus site) 74 CitationsAbstract
CONTEXT: Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established.
OBJECTIVE: To evaluate the state of the art in measuring 10 routine chemistry analytes.
DESIGN: A specimen prepared as off-the-clot pooled sera and 4 conventionally prepared specimens were sent to participants in the College of American Pathologists Chemistry Survey. Analyte concentrations were assigned by reference measurement procedures.
PARTICIPANTS: Approximately 6000 clinical laboratories.
RESULTS: For glucose, iron, potassium, and uric acid, more than 87.5% of peer groups meet the desirable bias goals based on biologic variability criteria. The remaining 6 analytes had less than 52% of peer groups that met the desirable bias criteria.
CONCLUSIONS: Routine measurement procedures for some analytes had acceptable traceability to reference systems. Conventionally prepared proficiency testing specimens were not adequately commutable with a fresh frozen specimen to be used to evaluate trueness of methods compared with a reference measurement procedure.
Author List
Miller WG, Myers GL, Ashwood ER, Killeen AA, Wang E, Ehlers GW, Hassemer D, Lo SF, Seccombe D, Siekmann L, Thienpont LM, Toth AAuthor
Stanley F. Lo PhD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood Chemical AnalysisChemistry, Clinical
Humans
Laboratories
Pathology, Clinical
Quality Control
Reference Values
Reproducibility of Results
United States
