Medical College of Wisconsin
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Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation. Cancer Lett 2014 Dec 28;355(2):210-6

Date

09/30/2014

Pubmed ID

25264923

Pubmed Central ID

PMC4301604

DOI

10.1016/j.canlet.2014.08.033

Scopus ID

2-s2.0-84908214686 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Cell division cycle 42 (CDC42), a small GTPase of the Rho-subfamily, regulates diverse cellular functions including proliferation, cytoskeletal rearrangement and even promotes malignant transformation. Here, we found that increased expression of CDC42 correlated with undifferentiated neuroblastoma as compared to a more benign phenotype. CDC42 inhibition decreased cell growth and soft agar colony formation, and increased cell death in BE(2)-C and BE(2)-M17 cell lines, but not in SK-N-AS. In addition, silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells. Our findings suggest that CDC42 may play a role in the regulation of aggressive neuroblastoma behavior.

Author List

Lee S, Craig BT, Romain CV, Qiao J, Chung DH

Author

Brian T. Craig MD Assistant Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Humans
N-Myc Proto-Oncogene Protein
Neuroblastoma
Nuclear Proteins
Oncogene Proteins
Proto-Oncogene Proteins c-myc
cdc42 GTP-Binding Protein