Epilepsy surgery outcomes: quality of life and seizure control. Pediatr Neurol 2010 Jan;42(1):12-20
Date
12/17/2009Pubmed ID
20004857DOI
10.1016/j.pediatrneurol.2009.07.018Scopus ID
2-s2.0-71149105109 (requires institutional sign-in at Scopus site) 57 CitationsAbstract
A consecutive, retrospective analysis of seizure control and quality of life was performed among 83 pediatric patients undergoing epilepsy surgery at Children's Hospital of Wisconsin. Seizure outcomes were generally favorable, with 68.7% class I outcomes; class II, 12%; and class III, 19.3%. Seizure freedom was highest among temporal lobectomies (84.2%) and hemispherectomies (76.2%). Outcomes among hemispherectomies were substantially superior to those of multilobar resections. Cortical dysplasia was associated with lower seizure freedom, at 57.5%. Among age groups, seizure-free outcomes in infants were lowest, at 50%. The lower infant seizure-free rate was likely attributable to frequency of multilobar resections and type of pathology (cortical dysplasia). Quality-of-life measures generally paralleled seizure outcomes. These results indicate that epilepsy surgery in children with intractable epilepsy can result in significant improvements in seizure control, quality of life, and development. Anticipated type of surgery, presumed location of epileptogenic site, absence of a defined lesion on magnetic resonance imaging scan of the brain, and patient's age should not prevent surgical evaluations of children with intractable epilepsy.
Author List
Zupanc ML, Rubio EJ, Werner RR, Schwabe MJ, Mueller WM, Lew SM, Marcuccilli CJ, O'Connor SE, Chico MS, Eggener KA, Hecox KEAuthors
Sean Lew MD Chief, Professor in the Neurosurgery department at Medical College of WisconsinWade M. Mueller MD Professor in the Neurosurgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentAge Factors
Child
Child, Preschool
Epilepsy
Female
Follow-Up Studies
Humans
Infant
Male
Malformations of Cortical Development
Neurosurgical Procedures
Quality of Life
Retrospective Studies
Seizures
Treatment Outcome
Young Adult
