The nucleosome family: dynamic and growing. Structure 2009 Feb 13;17(2):160-71
Date
02/17/2009Pubmed ID
19217387DOI
10.1016/j.str.2008.12.016Scopus ID
2-s2.0-59649087452 (requires institutional sign-in at Scopus site) 151 CitationsAbstract
Ever since the discovery of the nucleosome in 1974, scientists have stumbled upon discrete particles in which DNA is wrapped around histone complexes of different stoichiometries: octasomes, hexasomes, tetrasomes, "split" half-nucleosomes, and, recently, bona fide hemisomes. Do all these particles exist in vivo? Under what conditions? What is their physiological significance in the complex DNA transactions in the eukaryotic nucleus? What are their dynamics? This review summarizes research spanning more than three decades and provides a new meaning to the term "nucleosome." The nucleosome can no longer be viewed as a single static entity: rather, it is a family of particles differing in their structural and dynamic properties, leading to different functionalities.
Author List
Zlatanova J, Bishop TC, Victor JM, Jackson V, van Holde KAuthor
Vaughn Jackson PhD Emeritus Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDNA
Histones
Humans
Models, Biological
Models, Molecular
Multigene Family
Nucleic Acid Conformation
Nucleosomes
Protein Binding
Protein Multimerization
