Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. Front Chem 2020;8:580899
Date
10/27/2020Pubmed ID
33102447Pubmed Central ID
PMC7545953DOI
10.3389/fchem.2020.580899Scopus ID
2-s2.0-85092384929 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments.
Author List
Sikora A, Zielonka J, Dębowska K, Michalski R, Smulik-Izydorczyk R, Pięta J, Podsiadły R, Artelska A, Pierzchała K, Kalyanaraman BAuthors
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinJacek M. Zielonka PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin
