Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. Neuron 1995 Oct;15(4):857-66
Date
10/01/1995Pubmed ID
7576634DOI
10.1016/0896-6273(95)90176-0Scopus ID
2-s2.0-0028805976 (requires institutional sign-in at Scopus site) 46 CitationsAbstract
The avian ciliary ganglion contains choroid neurons that innervate choroid vasculature and express somatostatin as well as ciliary neurons that innervate iris/ciliary body but do not express somatostatin. We have previously shown in culture that activin A induces somatostatin immunoreactivity in both neuron populations. We now show in vivo that both targets contain activin A; however, choroid expressed higher levels of activin A mRNA. In contrast, follistatin, an activin A inhibitor, was higher in iris/ciliary body. Iris cell-conditioned medium also contained an activity that inhibited activin A and could be depleted with anti-follistatin antibodies. These results suggest that development of somatostatin is limited to choroid neurons by differential expression of activin A and follistatin in ciliary ganglion targets.
Author List
Darland DC, Link BA, Nishi RAuthor
Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ActivinsAlternative Splicing
Amino Acid Sequence
Animals
Chick Embryo
Choroid
Culture Media, Conditioned
Follistatin
Ganglia, Parasympathetic
Gene Expression
Glycoproteins
Immunoenzyme Techniques
Inhibins
Iris
Molecular Sequence Data
Neurons
Phenotype
Somatostatin