Medical College of Wisconsin
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Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. Neuron 1995 Oct;15(4):857-66

Date

10/01/1995

Pubmed ID

7576634

DOI

10.1016/0896-6273(95)90176-0

Scopus ID

2-s2.0-0028805976   45 Citations

Abstract

The avian ciliary ganglion contains choroid neurons that innervate choroid vasculature and express somatostatin as well as ciliary neurons that innervate iris/ciliary body but do not express somatostatin. We have previously shown in culture that activin A induces somatostatin immunoreactivity in both neuron populations. We now show in vivo that both targets contain activin A; however, choroid expressed higher levels of activin A mRNA. In contrast, follistatin, an activin A inhibitor, was higher in iris/ciliary body. Iris cell-conditioned medium also contained an activity that inhibited activin A and could be depleted with anti-follistatin antibodies. These results suggest that development of somatostatin is limited to choroid neurons by differential expression of activin A and follistatin in ciliary ganglion targets.

Author List

Darland DC, Link BA, Nishi R

Author

Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Activins
Alternative Splicing
Amino Acid Sequence
Animals
Chick Embryo
Choroid
Culture Media, Conditioned
Follistatin
Ganglia, Parasympathetic
Gene Expression
Glycoproteins
Immunoenzyme Techniques
Inhibins
Iris
Molecular Sequence Data
Neurons
Phenotype
Somatostatin
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0