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New Prognostic Indicators in Pediatric Adrenal Tumors: Neuroblastoma and Adrenal Cortical Tumors, Can We Predict When These Will Behave Badly? Surg Pathol Clin 2020 Dec;13(4):625-641

Date

11/14/2020

Pubmed ID

33183724

DOI

10.1016/j.path.2020.08.002

Scopus ID

2-s2.0-85092229346   2 Citations

Abstract

Pediatric adrenal tumors are unique entities with specific diagnostic, prognostic, and therapeutic challenges. The adrenal medulla gives rise to peripheral neuroblastic tumors (pNTs), pathologically defined by their architecture, stromal content, degree of differentiation, and mitotic-karyorrhectic index. Successful risk stratification of pNTs uses patient age, stage, tumor histology, and molecular/genetic aberrations. The adrenal cortex gives rise to adrenocortical tumors (ACTs), which present diagnostic and prognostic challenges. Histologic features that signify poor prognosis in adults can be meaningless in children, who have superior outcomes. The key clinical, pathologic, and molecular findings of pediatric ACTs have yet to be completely identified.

Author List

Jarzembowski JA

Author

Jason A. Jarzembowski MD, PhD Sr Associate Dean, CEO CSG, Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Neoplasms
Age Factors
Biomarkers, Tumor
Humans
Immunohistochemistry
Mutation
Neoplasm Staging
Neuroblastoma
Prognosis
Tumor Suppressor Protein p53