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Plegia to walking: AHSCBMT in severe NMOSD relapse BMJ Neurology Open BMJ Neurology Open 2020;2:e000073. doi:10.1136/ bmjno-2020-000073




Objectives Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% of patients with optic neuritis attacks have no or a partial recovery.

Methods Results from The European Group for Blood and Marrow Transplantation Autoimmune Diseases Working Party imply failure of autologous haematopoietic stem cell bone marrow transplantation.

Results and conclusion We present a case that despite eventual relapse, made a remarkable functional recovery after bone marrow transplantation which may justify bone marrow transplantation in severe cases.

Author List

Nicola Carlisle,1 Parameswaran Hari,2 Staley Brod


Staley A. Brod MD Professor in the Neurology department at Medical College of Wisconsin