C-reactive protein and copeptin: prognostic predictors in chronic obstructive pulmonary disease exacerbations. Curr Opin Pulm Med 2009 Mar;15(2):120-5
Date
06/18/2009Pubmed ID
19532026DOI
10.1097/MCP.0b013e3283218603Scopus ID
2-s2.0-62349134599 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
PURPOSE OF REVIEW: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a natural event in the course of COPD and remains a major cause of morbidity and mortality associated with this disease. Clinical criteria that define an acute exacerbation are subjective and open for debate. Identifying biomarkers that would be easily measured and followed in patients with acute exacerbation of COPD seems to be highly attractive. The aim of this review is to assess the role of biomarkers, C-reactive protein (CRP) and copeptin, as prognostic predictors in COPD exacerbations.
RECENT FINDINGS: Many pulmonary biomarkers have been extensively studied in the recent years. CRP and copeptin have gained particular interest. Recent data suggest that CRP is elevated during an acute exacerbation of COPD but CRP alone is neither sensitive nor specific in predicting clinical severity or outcome. Copeptin increases during acute exacerbation of COPD and may correlate with disease severity.
SUMMARY: Further studies are needed to determine the role of CRP and copeptin as biomarkers that aid in diagnosis and clinical outcome in acute exacerbation of COPD.
Author List
Antonescu-Turcu AL, Tomic RAuthor
Andreea Antonescu-Turcu MD Vice Chair, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersC-Reactive Protein
Glycopeptides
Humans
Predictive Value of Tests
Prognosis
Pulmonary Disease, Chronic Obstructive
Severity of Illness Index
