Faculty Collaboration Database

Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. Am J Physiol Renal Physiol 2018 Apr 01;314(4):F543-F550

Date

11/17/2017

Pubmed ID

29141938

Pubmed Central ID

PMC5966759

DOI

10.1152/ajprenal.00373.2017

Scopus ID

2-s2.0-85038850979 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Pudendal nerve stimulation is a promising treatment approach for lower urinary tract dysfunction, including symptoms of overactive bladder. Despite some promising clinical studies, there remain many unknowns as to how best to stimulate the pudendal nerve to maximize therapeutic efficacy. We quantified changes in bladder capacity and voiding efficiency during single-fill cystometry in response to electrical stimulation of the sensory branch of the pudendal nerve in urethane-anesthetized female Wistar rats. Increases in bladder capacity were dependent on both stimulation amplitude and rate. Stimulation that produced increases in bladder capacity also led to reductions in voiding efficiency. Also, there was a stimulation carryover effect, and increases in bladder capacity persisted during several nonstimulated trials following stimulated trials. Intravesically administered PGE₂ reduced bladder capacity, producing a model of overactive bladder (OAB), and sensory pudendal nerve stimulation again increased bladder capacity but also reduced voiding efficiency. This study serves as a basis for future studies that seek to maximize the therapeutic efficacy of sensory pudendal nerve stimulation for the symptoms of OAB.

Author List

Hokanson JA, Langdale CL, Sridhar A, Grill WM

Author

James A. Hokanson PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Dinoprostone
Disease Models, Animal
Electric Stimulation Therapy
Female
Pudendal Nerve
Rats, Wistar
Urinary Bladder
Urinary Bladder, Overactive
Urodynamics