Resistance of zinc-supplemented Candida albicans cells to the growth inhibitory effect of calprotectin. J Infect Dis 1995 May;171(5):1289-94
Date
05/01/1995Pubmed ID
7751705DOI
10.1093/infdis/171.5.1289Scopus ID
2-s2.0-0028929257 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
Calprotectin is a neutrophil cytoplasmic protein with significant microbistatic activity. This protein may compete for zinc, or the metal may inactivate a different microbistatic activity of the protein. To distinguish between these possibilities, the sensitivity to calprotectin was determined for zinc-supplemented Candida albicans cells. The latter had increased growth in cultures containing either human empyema fluid as a source of calprotectin or purified calprotectin itself. This increased growth did not appear to be due to leakage of zinc into the medium. In other experiments, empyema fluid supernatants did not suppress C. albicans growth across a dialysis membrane; however, other studies suggested that it is difficult to significantly suppress C. albicans growth by zinc depletion unless the depleting agent remains in the cultures. These results indicate that calprotectin inhibits C. albicans growth through competition for zinc.
Author List
Santhanagopalan V, Hahn BL, Sohnle PGAuthor
Peter G. Sohnle MS, MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Candida albicansCell Adhesion Molecules, Neuronal
Cell Division
Drug Resistance, Microbial
Empyema
Humans
Leukocyte L1 Antigen Complex
Zinc
