Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease. Mol Metab 2021 Aug;50:101119
Date
11/22/2020Pubmed ID
33220489Pubmed Central ID
PMC8324695DOI
10.1016/j.molmet.2020.101119Scopus ID
2-s2.0-85097478750 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
BACKGROUND: As a result of a sedentary lifestyle and excess food consumption in modern society, non-alcoholic fatty liver disease (NAFLD) characterized by fat accumulation in the liver is becoming a major disease burden. Non-alcoholic steatohepatitis (NASH) is an advanced form of NAFLD characterized by inflammation and fibrosis that can lead to hepatocellular carcinoma and liver failure. Nuclear receptors (NRs) are a family of ligand-regulated transcription factors that closely control multiple aspects of metabolism. Their transcriptional activity is modulated by various ligands, including hormones and lipids. NRs serve as potential pharmacological targets for NAFLD/NASH and other metabolic diseases.
SCOPE OF REVIEW: In this review, we provide a comprehensive overview of NRs that have been studied in the context of NAFLD/NASH with a focus on their transcriptional regulation, function in preclinical models, and studies of their clinical utility.
MAJOR CONCLUSIONS: The transcriptional regulation of NRs is context-dependent. During the dynamic progression of NAFLD/NASH, NRs play diverse roles in multiple organs and different cell types in the liver, which highlights the necessity of targeting NRs in a stage-specific and cell-type-specific manner to enhance the efficacy and safety of treatment methods.
Author List
Xiao Y, Kim M, Lazar MAAuthor
Yang Xiao Assistant Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDisease Models, Animal
Gene Expression Regulation
Humans
Lipid Metabolism
Liver
Non-alcoholic Fatty Liver Disease
Receptors, Cytoplasmic and Nuclear
Transcription Factors
Transcriptional Activation
