Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease. J Neurosci 2021 Feb 03;41(5):845-854

Date

01/22/2021

Pubmed ID

33472820

Pubmed Central ID

PMC7880285

DOI

10.1523/JNEUROSCI.1654-20.2020

Scopus ID

2-s2.0-85101994444   19 Citations

Abstract

Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.

Author List

Zholudeva LV, Abraira VE, Satkunendrarajah K, McDevitt TC, Goulding MD, Magnuson DSK, Lane MA

Author

Kajana Satkunendrarajah PhD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
GABA Agonists
Humans
Interneurons
Nervous System Diseases
Neuronal Plasticity
Neurons
Spinal Cord
Spinal Cord Injuries