Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res 2005 Jul;24(4):433-56
Date
04/23/2005Pubmed ID
15845344DOI
10.1016/j.preteyeres.2005.01.003Scopus ID
2-s2.0-17544369648 (requires institutional sign-in at Scopus site) 331 CitationsAbstract
Circadian clocks are self-sustaining genetically based molecular machines that impose approximately 24h rhythmicity on physiology and behavior that synchronize these functions with the solar day-night cycle. Circadian clocks in the vertebrate retina optimize retinal function by driving rhythms in gene expression, photoreceptor outer segment membrane turnover, and visual sensitivity. This review focuses on recent progress in understanding how clocks and light control arylalkylamine N-acetyltransferase (AANAT), which is thought to drive the daily rhythm in melatonin production in those retinas that synthesize the neurohormone; AANAT is also thought to detoxify arylalkylamines through N-acetylation. The review will cover evidence that cAMP is a major output of the circadian clock in photoreceptor cells; and recent advances indicating that clocks and clock networks occur in multiple cell types of the retina.
Author List
Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SSAuthor
Shyam S. Chaurasia PhD Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsArylamine N-Acetyltransferase
Biological Clocks
Circadian Rhythm
Cyclic AMP
Humans
Light
Melatonin
Retina
