Sympathetic activation with desflurane in humans. Adv Pharmacol 1994;31:369-78
Date
01/01/1994Pubmed ID
7873424DOI
10.1016/s1054-3589(08)60629-8Scopus ID
2-s2.0-0028696007 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Although the blood pressure lowering effects of desflurane and isoflurane were similar at equi-MAC, we noted a different pattern of response during intervals of rapidly increasing the inspired concentration of desflurane, when substantial increases in SNA, HR, and MAP occurred. Because of the lower potency of desflurane compared to isoflurane, higher concentrations of desflurane are necessary to establish an adequate surgical plane of anesthesia. Although clinically relevant concentrations of isoflurane did not trigger sympathetic activation, isoflurane triggered responses at an inspired concentration (approximately 5%) nearly equal to that of desflurane. The present research demonstrates that the initial exposure to desflurane in clinically relevant concentrations following anesthetic induction and the deepening of anesthesia with higher concentrations of desflurane can be profoundly sympatho-excitatory. Considerable caution should be taken when administering desflurane to patients who may be placed at risk by these responses.
Author List
Ebert TJ, Muzi MAuthor
Thomas J. Ebert MD, PhD Adjunct Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnesthetics
Blood Pressure
Heart Rate
Humans
Isoflurane
Male
Sympathetic Nervous System