Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments. Biochem Biophys Res Commun 1985 Sep 16;131(2):659-65
Date
09/16/1985Pubmed ID
2996521DOI
10.1016/0006-291x(85)91288-4Scopus ID
2-s2.0-0022407173 (requires institutional sign-in at Scopus site) 57 CitationsAbstract
The hydrogen peroxide produced during the autoxidation of melanin pigments has been measured using an oxidase electrode. The autoxidation has been shown to occur via the superoxide intermediate. The melanin pigment competes with superoxide dismutase for the scavenging of superoxide radicals. However, superoxide dismutase at high concentrations caused a substantial increase in the production of hydrogen peroxide, formed during melanin autoxidation. The implications of this finding are discussed in light of melanin's ability to function as a pseudo-dismutase.
Author List
Korytowski W, Hintz P, Sealy RC, Kalyanaraman BAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCattle
Dihydroxyphenylalanine
Hydrogen Peroxide
Hydrogen-Ion Concentration
Melanins
Oxidation-Reduction
Superoxide Dismutase
Superoxides