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"Peppering the pons": CLIPPERS or myelin oligodendrocyte glycoprotein associated disease? Mult Scler Relat Disord 2021 Jun;51:102874



Pubmed ID




Scopus ID

2-s2.0-85102657644 (requires institutional sign-in at Scopus site)   6 Citations


Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a distinct pathologic entity of unknown etiology. Here, we describe the clinical and radiologic presentation of myelin oligodendrocyte glycoprotein associated disease (MOG-AD) with features mimicking CLIPPERS. Three patients met the 2017 CLIPPERS diagnostic criteria, while one patient had a single lesion in the pons that mimicked CLIPPERS lesions. All had an excellent response to steroids, but the three who met the CLIPPERS criteria had a relapsing course. When CLIPPERS is observed, it is crucial to test for mimickers. The ever-expanding spectrum of MOG-AD calls for further research into the immunopathogenesis of its several phenotypes.

Author List

Obeidat AZ, Block AN, Hooshmand SI


Sam I. Hooshmand DO Assistant Professor in the Neurology department at Medical College of Wisconsin
Ahmed Zayed Obeidat MD, PhD Associate Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Magnetic Resonance Imaging
Myelin-Oligodendrocyte Glycoprotein