Faculty Collaboration Database

High-resolution magnetic resonance imaging evaluation of blood-retinal barrier integrity following transscleral diode laser treatment. Arch Ophthalmol 1995 Jan;113(1):96-102

Date

01/01/1995

Pubmed ID

7826300

DOI

10.1001/archopht.1995.01100010098027

Scopus ID

2-s2.0-0028854568 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

OBJECTIVE: To compare the effects of contact transscleral diode laser treatment and retinal cryotherapy on blood-retinal barrier integrity with the use of high-resolution magnetic resonance imaging techniques with constant infusion of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA).

METHODS: Transscleral diode laser photocoagulation and retinal cryotherapy were used to treat equivalent areas of the inferior retinal periphery of pigmented rabbits. Magnetic resonance imaging time-course studies with measurement of signal enhancements due to Gd-DTPA leakage were conducted 2 and 15 days following treatment.

RESULTS: Two days following treatment, cryotherapy-treated eyes exhibited a mean (+/- SD) effective Gd-DTPA permeability coefficient of 4.6 +/- 0.8 x 10(-6) cm/s; in comparison, diode laser-treated eyes exhibited 1.6 x 1.4 x 10(-6) cm/s effective permeability. Significant decreases in the effective permeability were also noted 15 days after treatment in both groups.

CONCLUSIONS: Transscleral contact probe diode laser photocoagulation induces less disruption of the blood-retinal barrier than does conventional cryotherapy. In addition, the continuous infusion method of Gd-DTPA delivery is a reliable and easily interpretable alternative to the commonly used bolus injection approach.

Author List

Arrindell EL, Wu JC, Wolf MD, Nanda S, Han DP, Wong EC, Abrams GW, Mieler WF, Hyde JS

Author

Dennis Han MD Emeritus Professor in the Ophthalmology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood-Retinal Barrier
Cell Membrane Permeability
Cryotherapy
Gadolinium DTPA
Infusions, Intravenous
Laser Coagulation
Magnetic Resonance Imaging
Organometallic Compounds
Pentetic Acid
Rabbits
Random Allocation
Retina
Sclera