Frontal and parietal lobe dysfunction in depression: delayed alternation and tactile learning deficits. Neuropsychologia 1994 Aug;32(8):1015-25
Date
08/01/1994Pubmed ID
7969863DOI
10.1016/0028-3932(94)90050-7Scopus ID
2-s2.0-0028085616 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
To evaluate frontal and parietal lobe involvement in depression, behavioral tests sensitive to damage in these regions were administered to depressed patients over age 50. Delayed alternation (DA), delayed response and object alternation were used to assess dorsolateral frontal and orbitofrontal function. Tactile learning problems (TOL and TRL) assessed parietal lobe integrity. Depressed patients were significantly impaired on DA, TOL and TRL, suggesting spatial memory (DA) and tactile learning deficits. The functional neuroanatomy underlying these deficits may share features with Parkinson's and Alzheimer's diseases.
Author List
Freedman MAuthor
Mark Barash DO Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAlzheimer Disease
Depressive Disorder
Diagnosis, Differential
Frontal Lobe
Humans
Middle Aged
Parietal Lobe
Parkinson Disease
Space Perception
Touch