Medical College of Wisconsin
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Frontal and parietal lobe dysfunction in depression: delayed alternation and tactile learning deficits. Neuropsychologia 1994 Aug;32(8):1015-25

Date

08/01/1994

Pubmed ID

7969863

DOI

10.1016/0028-3932(94)90050-7

Scopus ID

2-s2.0-0028085616 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

To evaluate frontal and parietal lobe involvement in depression, behavioral tests sensitive to damage in these regions were administered to depressed patients over age 50. Delayed alternation (DA), delayed response and object alternation were used to assess dorsolateral frontal and orbitofrontal function. Tactile learning problems (TOL and TRL) assessed parietal lobe integrity. Depressed patients were significantly impaired on DA, TOL and TRL, suggesting spatial memory (DA) and tactile learning deficits. The functional neuroanatomy underlying these deficits may share features with Parkinson's and Alzheimer's diseases.

Author List

Freedman M

Author

Mark Barash DO Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Alzheimer Disease
Depressive Disorder
Diagnosis, Differential
Frontal Lobe
Humans
Middle Aged
Parietal Lobe
Parkinson Disease
Space Perception
Touch