Faculty Collaboration Database

Anterior communicating artery aneurysm paraparesis syndrome: clinical manifestations and pathologic correlates. Neurology 1995 Jan;45(1):45-50

Date

01/01/1995

Pubmed ID

7824133

DOI

10.1212/wnl.45.1.45

Scopus ID

2-s2.0-0028861311 (requires institutional sign-in at Scopus site)   38 Citations

Abstract

OBJECTIVE: Clinicopathologic evaluation of patients with lower extremity paraparesis/-plegia following rupture and repair of anterior communicating artery (ACoA) aneurysms.

DESIGN: Institution-based retrospective review.

SETTING: A tertiary neurologic referral center.

PATIENTS, PARTICIPANTS: Seven of 101 patients with subarachnoid hemorrhage from ruptured ACoA aneurysms treated between January 1987 and December 1992.

MAIN OUTCOME MEASURES: Neurologic status at latest follow-up examination.

RESULTS: All patients presented with severe hemorrhage, poor clinical grade, and intracranial hypertension. Motor deficits developed within 7 days of aneurysm rupture and persisted for a mean duration of 39 days. Angiographic evidence of vasospasm in the anterior cerebral artery (ACA) distribution was documented in all cases, and paraparesis persisted beyond the angiographic resolution of vasospasm. All patients had evidence of frontal lobe dysfunction throughout their postoperative courses, and deep venous thrombosis and pulmonary emboli were common causes of morbidity and mortality. Autopsy data supported regional microvascular ischemia within the ACA distribution as the etiology of these motor deficits.

CONCLUSIONS: The combination of vasospasm in the ACA distribution and lower extremity weakness associated with cognitive and affective impairment that resolves with time is common in patients with ACoA aneurysms. We propose that this constellation of clinical, radiographic, and pathologic findings be referred to as the "ACoA aneurysm paraparesis syndrome."

Author List

Greene KA, Marciano FF, Dickman CA, Coons SW, Johnson PC, Bailes JE, Spetzler RF

Author

Karl A. Greene MD Adjunct Assistant Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Autopsy
Brain
Brain Ischemia
Cerebral Angiography
Cerebrovascular Circulation
Female
Humans
Intracranial Aneurysm
Male
Microcirculation
Middle Aged
Neurologic Examination
Paralysis
Pulmonary Embolism
Retrospective Studies
Subarachnoid Hemorrhage
Thrombosis
Tomography, X-Ray Computed
Treatment Outcome