Faculty Collaboration Database

The effect of chronic alprazolam on sleep and bioamine metabolites in depression. J Clin Psychopharmacol 1994 Feb;14(1):36-40

Date

02/01/1994

Pubmed ID

7512100

Scopus ID

2-s2.0-0028316193 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Alprazolam administered for 43 days in doses of 6 to 10 mg/day had an antidepressant effect in four of nine depressed patients. Decreases in slow wave sleep, increases in rapid eye movement (REM) latency, and decreases in REM minutes and percent and REM sleep eye movements were found in the group as a whole. The drug had a general hypnotic effect with a trend toward increased total sleep time. Nonsignificant changes in the concentrations of 3-methyl-4-hydroxyphenylglycol and homovanillic acid in the cerebrospinal fluid (CSF) were qualitatively similar to those found after treatment with tricyclic antidepressant drugs; however, only the larger decreases in CSF 5-hydroxyindoleacetic acid achieved statistical significance. Baseline sleep and CSF metabolites and changes in these measures on drug did not predict the therapeutic effects of alprazolam.

Author List

Zarcone VP Jr, Benson KL, Greene KA, Csernansky JG, Faull KF

Author

Karl A. Greene MD Adjunct Assistant Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Alprazolam
Depressive Disorder
Double-Blind Method
Homovanillic Acid
Humans
Hydroxyindoleacetic Acid
Male
Methoxyhydroxyphenylglycol
Middle Aged
Personality Inventory
Polysomnography
Sleep Stages
Sleep, REM