Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 2009 Nov;9(11):785-97
Date
10/24/2009Pubmed ID
19851314Pubmed Central ID
PMC3616489DOI
10.1038/nrc2696Scopus ID
2-s2.0-70350518233 (requires institutional sign-in at Scopus site) 775 CitationsAbstract
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating the RB pathway have been identified in almost every human malignancy. The E2F transcription factors function in cell cycle control and are intimately regulated by RB. Studies of model organisms have revealed conserved functions for E2Fs during development, suggesting that the cancer-related proliferative roles of E2F family members represent a recent evolutionary adaptation. However, given that some human tumours have concurrent RB1 inactivation and E2F amplification and overexpression, we propose that there are alternative tumour-promoting activities for the E2F family, which are independent of cell cycle regulation.
Author List
Chen HZ, Tsai SY, Leone GAuthors
Hui-Zi Chen MD, PhD Assistant Professor in the Medicine department at Medical College of WisconsinGustavo Leone PhD Sr Associate Dean, Director, Professor in the Biochemistry department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsCell Cycle
E2F Transcription Factors
Humans
Multigene Family
Neoplasms
Retinoblastoma Protein
