Faculty Collaboration Database

Trabeculectomy with mitomycin C in glaucoma associated with uveitis. Ophthalmic Surg 1994;25(9):616-20

Date

09/01/1994

Pubmed ID

7831006

Scopus ID

2-s2.0-0027944078 (requires institutional sign-in at Scopus site)   88 Citations

Abstract

Twenty-four trabeculectomies performed in 24 patients for control of uveitic glaucoma were retrospectively evaluated to analyze the effect of intraoperative application of mitomycin C (MMC) on the short-term outcome of trabeculectomy for glaucoma associated with uveitis. Success rates, postoperative levels of intraocular pressure (IOP), and complications were studied. After a mean follow up of 9.87 months (range, 3 to 27 months), 18 eyes (75%) achieved an IOP of 21 mm Hg or less without antiglaucoma medications. The same IOP level with one antiglaucoma medication was achieved in four eyes (16.6%). Statistical analysis demonstrated a significant reduction in IOP postoperatively during the period studied (P = .0001). Complications observed included exacerbation of the uveitis (12.5%), choroidal detachment (12.5%), hypotony (8.3%), postoperative shallow anterior chamber (4.2%), wound leak (4.2%), hyphema (4.2%), and macular edema (4.2%). The results of this retrospective and uncontrolled study suggest that intraoperative application of MMC may be a good option for enhancement of short-term trabeculectomy success rates in cases of uveitic glaucoma.

Author List

Prata JA Jr, Neves RA, Minckler DS, Mermoud A, Heuer DK

Author

Dale Heuer MD Emeritus Professor in the Ophthalmology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Glaucoma
Humans
Intraocular Pressure
Intraoperative Care
Male
Middle Aged
Mitomycin
Postoperative Complications
Retrospective Studies
Trabeculectomy
Treatment Outcome
Uveitis