Faculty Collaboration Database

Fluid management, electrolytes imbalance and renal management in neonates with neonatal encephalopathy treated with hypothermia. Semin Fetal Neonatal Med 2021 Aug;26(4):101261

Date

06/19/2021

Pubmed ID

34140246

DOI

10.1016/j.siny.2021.101261

Scopus ID

2-s2.0-85107997163 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

Kidney dysfunction and acute kidney injury (AKI) frequently accompanies neonatal encephalopathy and contributes to neonatal morbidity and mortality. While there are currently no proven therapies for the treatment of AKI, understanding the pathophysiology along with early recognition and treatment of alterations in fluid, electrolyte and metabolic homeostasis that accompany AKI offer opportunity to reduce associated morbidity. Promising new tests and technologies, including urine and serum biomarkers and renal near-infrared spectroscopy offer opportunities to improve diagnosis and monitoring of neonates at risk for kidney injury. Furthermore, recent advances in neonatal kidney supportive therapies such as hemofiltration and hemodialysis may further improve outcomes in this population. This chapter provides an overview of disorders of fluid balance, electrolyte homeostasis and kidney function associated with neonatal encephalopathy and therapeutic hypothermia. Recommendations for fluid and electrolyte management based upon published literature and authors' opinions are provided.

Author List

Segar JL, Chock VY, Harer MW, Selewski DT, Askenazi DJ, Newborn Brain Society Guidelines and Publications Committee

Author

Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Kidney Injury
Asphyxia Neonatorum
Humans
Hypothermia
Hypothermia, Induced
Hypoxia-Ischemia, Brain
Infant, Newborn
Kidney