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A limited panel of INSM1 and LEF1 immunostains accurately distinguishes between pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm. Pathol Res Pract 2021 Jul;223:153462

Date

05/29/2021

Pubmed ID

34048981

DOI

10.1016/j.prp.2021.153462

Scopus ID

2-s2.0-85106525189

Abstract

Solid pseudopapillary neoplasm (SPN) and well differentiated pancreatic neuroendocrine tumor (PNET) can show significant cytomorphological overlap. In this study, we evaluated the role of INSM1 and LEF1 immunohistochemical stains in distinguishing between these two tumors. 22 SPN and 25 PNET surgically resected cases were stained for both INSM1 and LEF1. All the 22 cases of SPN showed strong and diffuse nuclear staining for LEF1 (in >95 % of tumor cells), while all 25 PNET were negative for LEF1. All 25 PNET cases were positive for INSM1 (moderate to strong intensity nuclear staining in >50 % of the tumor cells), while all 22 cases of SPN were negative for INSM1. The results of our study show that a limited panel comprising of INSM1 and LEF1 immunostains accurately distinguishes between SPN and PNET.

Author List

Guo W, Farzaneh T, Lee W, Nael A, Li X, Chandan VS

Author

Whayoung Lee MD Assistant Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Child
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Lymphoid Enhancer-Binding Factor 1
Male
Middle Aged
Neuroendocrine Tumors
Pancreatic Neoplasms
Predictive Value of Tests
Repressor Proteins
Young Adult