miR-204: Molecular Regulation and Role in Cardiovascular and Renal Diseases. Hypertension 2021 Aug;78(2):270-281
Date
06/29/2021Pubmed ID
34176282Pubmed Central ID
PMC8283800DOI
10.1161/HYPERTENSIONAHA.121.14536Scopus ID
2-s2.0-85109560313 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
The field of microRNA research has evolved from studies aiming to gauge the importance of microRNAs to those focusing on understanding a subset of specific microRNAs that have emerged as potent regulators of molecular systems and pathophysiological conditions. In this article, we review the molecular features and regulation of miR-204 and the growing body of evidence for an important role of miR-204 in the regulation of cardiovascular and renal physiology and pathophysiological processes. miR-204 exhibits a highly tissue-specific expression pattern, and miR-204 abundance is regulated by several transcriptional and posttranscriptional mechanisms. Strong evidence supports a role for miR-204 in attenuating pulmonary arterial hypertension and hypertensive and diabetic renal injury while promoting hypertension and endothelial dysfunction in a wide range of model systems. miR-204 may influence these disease processes by targeting several biological pathways in a tissue-specific manner. miR-204 is dysregulated in patients with cardiovascular and renal diseases. The unequivocal functional roles and clear clinical relevance indicate that miR-204 is a high-value microRNA in cardiovascular and renal diseases.
Author List
Liu J, Liu Y, Wang F, Liang MMESH terms used to index this publication - Major topics in bold
Blood VesselsCardiovascular Diseases
Humans
Kidney
Kidney Diseases
MicroRNAs
Myocardium