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Maternal ABO Blood Type and Factors Associated With Preeclampsia Subtype. Biol Res Nurs 2019 May;21(3):264-271



Pubmed ID




Scopus ID

2-s2.0-85063033283 (requires institutional sign-in at Scopus site)   7 Citations


BACKGROUND: The pathophysiology of preeclampsia remains unclear. The disorder is heterogeneous, and the pathophysiology may vary by subtype. Identification of relevant biomarkers will help to better elucidate the pathophysiologic basis of each preeclampsia subtype. Blood type may be a biomarker that allows risk identification for preeclampsia.

OBJECTIVE: The purpose of this study was to investigate the associations among maternal ABO blood type and preeclampsia subtype and fetal growth restriction (FGR).

METHOD: Medical records of 126 women with early-onset preeclampsia (≤33 6/7 weeks' gestation), 126 women with late-onset preeclampsia (≥34 0/7 weeks' gestation), and 259 controls who gave birth between January 2012 and June 2016 were retrospectively abstracted from a large suburban tertiary referral center in South Central Pennsylvania for this hospital-based case-control study.

RESULTS: Women with AB blood type had >3 times the odds of late-onset preeclampsia (odds ratio [ OR] = 3.35, 95% confidence interval (CI) = [1.02, 11.05]) compared to those with O blood type. Among women with early-onset preeclampsia, those with B blood type had 5 times the odds of having a growth-restricted fetus than did women with O blood type ( OR = 5.44, 95% CI [1.65, 17.94]).

DISCUSSION: Our findings suggest that AB blood type may be an important risk factor for late-onset preeclampsia and that among women with early-onset preeclampsia, those with B blood type have increased odds of FGR. These findings warrant further study in women and their offspring to identify the pathophysiologic processes that may link ABO blood type, preeclampsia subtype, and FGR.

Author List

Burgess A, Johnson TS, Simanek A, Bell T, Founds S


Teresa Johnson PhD Associate Professor in the Nursing department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Blood Grouping and Crossmatching
Case-Control Studies
Fetal Growth Retardation
Odds Ratio
Retrospective Studies