Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex. Epilepsy Res 2013 Sep;106(1-2):280-3
Date
04/30/2013Pubmed ID
23623846Pubmed Central ID
PMC3758912DOI
10.1016/j.eplepsyres.2013.03.011Scopus ID
2-s2.0-84883296500 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Seizures in newborns are associated with a high risk for subsequent epilepsy and adverse neurodevelopmental consequences. Understanding the mechanisms by which neonatal seizures adversely disturb the immature brain is important in developing therapeutic strategies. Using the convulsant agent flurothyl to mimic repetitive neonatal seizures we show that early-life seizures result in long-term alteration in the maintenance phase of long-term potentiation (LTP) in layer IV to layer II/III synapses of the somatosensory cortex without alteration of basal synaptic transmission, the induction phase of LTP and short-term depression. Such alterations may have a role in functional deficits seen following neonatal seizures.
Author List
Isaeva E, Isaev D, Holmes GLAuthor
Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnimals, Newborn
Convulsants
Electroencephalography
Flurothyl
Neuronal Plasticity
Rats
Rats, Sprague-Dawley
Seizures
Somatosensory Cortex
Synapses