Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. Pharmacol Rep 2011;63(3):840-4

Date

08/23/2011

Pubmed ID

21857096

DOI

10.1016/s1734-1140(11)70597-7

Abstract

Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg²⁺ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg²⁺. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.

Author List

Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D

Author

Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Drug Delivery Systems
Hippocampus
Magnesium
Neuraminidase
Rats
Rats, Wistar
Sialic Acids
Status Epilepticus