Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. Pharmacol Rep 2011;63(3):840-4
Date
08/23/2011Pubmed ID
21857096DOI
10.1016/s1734-1140(11)70597-7Scopus ID
2-s2.0-80051523283 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg²⁺ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg²⁺. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.
Author List
Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev DAuthor
Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDisease Models, Animal
Drug Delivery Systems
Hippocampus
Magnesium
Neuraminidase
Rats
Rats, Wistar
Sialic Acids
Status Epilepticus