Medical College of Wisconsin
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[EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX]. Fiziol Zh (1994) 2015;61(6):11-6

Date

01/01/2015

Pubmed ID

27025040

DOI

10.15407/fz61.06.011

Scopus ID

2-s2.0-84988799233 (requires institutional sign-in at Scopus site)

Abstract

Using an experimental model of neonatal recurrent seizures we investigated the influence of epileptic seizures in the various forms of synaptic plasticity in neurons of the somatosensory cortex. We found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsynaptic potentials and the depression of postsynaptic potentials during high-frequency stimulation. However they result in the chronic increase of the long-term potentiation of synaptic transmission. These changes of synaptic plasticity may affect the processing of the sensory information in patients with a history of recurrent seizures during early development.

Author List

Isaeva EV, Lunko OO, Romano AK, Isaev DS

Author

Olena Isaeva PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Animals, Newborn
Convulsants
Epilepsy
Excitatory Postsynaptic Potentials
Flurothyl
Humans
Inhibitory Postsynaptic Potentials
Long-Term Potentiation
Male
Neurons
Rats, Sprague-Dawley
Somatosensory Cortex
Synaptic Transmission