Connectivity changes after laser ablation: Resting-state fMRI. Epilepsy Res 2018 May;142:156-160
Date
10/17/2017Pubmed ID
29031866DOI
10.1016/j.eplepsyres.2017.09.015Scopus ID
2-s2.0-85030833029 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Resting-state functional magnetic resonance imaging (rsfMRI) is emerging as a useful tool in the multimodal assessment of patients with epilepsy. In pediatric patients who cannot perform task-based fMRI, rsfMRI may present an adjunct and alternative. Although changes in brain activation during task-based fMRI have been described after surgery for epilepsy, there is limited data on the role of postoperative rsfMRI. In this short review, we discuss the role of postoperative rsfMRI after laser ablation of seizure foci. By establishing standardized anesthesia protocols and imaging parameters, we have been able to perform serial rsfMRI at postoperative follow-up. The development of in-house software that can merge rsfMRI images to surgical navigation systems has allowed us to enhance the clinical applications of this technique. Resting-state fMRI after laser ablation has the potential to identify changes in connectivity, localize new seizure foci, and guide antiepileptic therapy. In our experience, rsfMRI complements conventional MR imaging and task-based fMRI for the evaluation of patients with seizure recurrence after laser ablation, and represents a potential noninvasive biomarker for functional connectivity.
Author List
Boerwinkle VL, Vedantam A, Lam S, Wilfong AA, Curry DJAuthor
Aditya Vedantam MD Assistant Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Child, PreschoolElectroencephalography
Epilepsy
Female
Humans
Image Processing, Computer-Assisted
Laser Therapy
Magnetic Resonance Imaging
Neural Pathways
Oxygen
Rest