Accuracy of Cardiac Magnetic Resonance Imaging in Diagnosing Pediatric Cardiac Masses: A Multicenter Study. JACC Cardiovasc Imaging 2022 Aug;15(8):1391-1405
Date
08/23/2021Pubmed ID
34419404Pubmed Central ID
PMC11240235DOI
10.1016/j.jcmg.2021.07.010Scopus ID
2-s2.0-85135596644 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
BACKGROUND: After diagnosis of a cardiac mass, clinicians must weigh the benefits and risks of ascertaining a tissue diagnosis. Limited data are available on the accuracy of previously developed noninvasive pediatric cardiac magnetic resonance (CMR)-based diagnostic criteria.
OBJECTIVES: The goals of this study were to: 1) evaluate the CMR characteristics of pediatric cardiac masses from a large international cohort; 2) test the accuracy of previously developed CMR-based diagnostic criteria; and 3) expand diagnostic criteria using new information.
METHODS: CMR studies (children 0-18 years of age) with confirmatory histological and/or genetic diagnosis were analyzed by 2 reviewers, without knowledge of prior diagnosis. Diagnostic accuracy was graded as: 1) single correct diagnosis; 2) correct diagnosis among a differential; or 3) incorrect diagnosis.
RESULTS: Of 213 cases, 174 (82%) had diagnoses that were represented in the previously published diagnostic criteria. In 70% of 174 cases, both reviewers achieved a single correct diagnosis (94% of fibromas, 71% of rhabdomyomas, and 50% of myxomas). When ≤2 differential diagnoses were included, both reviewers reached a correct diagnosis in 86% of cases. Of 29 malignant tumors, both reviewers indicated malignancy as a single diagnosis in 52% of cases. Including ≤2 differential diagnoses, both reviewers indicated malignancy in 83% of cases. Of 6 CMR sequences examined, acquisition of first-pass perfusion and late gadolinium enhancement were independently associated with a higher likelihood of a single correct diagnosis.
CONCLUSIONS: CMR of cardiac masses in children leads to an accurate diagnosis in most cases. A comprehensive imaging protocol is associated with higher diagnostic accuracy.
Author List
Beroukhim RS, Ghelani S, Ashwath R, Balasubramanian S, Biko DM, Buddhe S, Campbell MJ, Cross R, Festa P, Griffin L, Grotenhuis H, Hasbani K, Hashemi S, Hegde S, Hussain T, Jain S, Kiaffas M, Kutty S, Lam CZ, Liberato G, Merlocco A, Misra N, Mowers KL, Muniz JC, Nutting A, Parra DA, Patel JK, Perez-Atayde AR, Prasad D, Rosental CF, Shah A, Samyn MM, Sleeper LA, Slesnick T, Valsangiacomo E, Geva TAuthor
Margaret Mary Samyn MD, MBA Assistant Dean, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ChildContrast Media
Gadolinium
Heart Neoplasms
Humans
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine
Predictive Value of Tests
Retrospective Studies
