Faculty Collaboration Database

Suppressed formation of bone marrow adherent layers derived from acute myeloid leukemia patients after in vitro exposure to interleukin-4. Leuk Res 1997 Jun;21(6):519-27

Date

06/01/1997

Pubmed ID

9279363

DOI

10.1016/s0145-2126(97)00005-2

Scopus ID

2-s2.0-0030929390 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

Long-term bone marrow cultures from ten acute myeloid leukemia (AML) patients exposed to recombinant human (rhu) interleukin (IL) 4 from culture initiation failed to develop adherent layers at 5 weeks as compared to controls. The adherent layers from two of our patients expressed IL-1 beta transcripts constitutively, and all produced IL-6 and leukemia inhibitory factor (LIF) proteins. Our results demonstrate that rhuIL-4 markedly inhibited AML-derived adherent layer formation in a time- and dose-dependent manner, and this effect was not mediated through enhanced apoptosis and did not correlate with IL-1 beta, IL-6 or LIF production.

Author List

Wetzler M, Kurzrock R, Estrov Z, Barone S, Estey E, Talpaz M

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Disease
Apoptosis
Bone Marrow
Cell Adhesion
Humans
Interleukin-4
Leukemia, Myeloid
Recombinant Proteins
Tumor Cells, Cultured