Faculty Collaboration Database

Molecular characteristics of chronic myelogenous leukemia in blast crisis. Cancer Genet Cytogenet 1987 Aug;27(2):349-56

Date

08/01/1987

Pubmed ID

3474057

DOI

10.1016/0165-4608(87)90018-5

Scopus ID

2-s2.0-0023217510 (requires institutional sign-in at Scopus site)   32 Citations

Abstract

We have studied the expression of c-abl and c-myc in leukemic cells of patients in all clinical phases of chronic myelogenous leukemia. We demonstrate that an aberrant 8-Kb c-abl related transcript is present in the RNA of the leukemic cell from all patients with Ph+ CML and that the loss of both normal chromosome #9 is associated with the loss of the normal c-abl related transcripts. This represents direct evidence that the normal c-abl related transcripts derive from the normal c-abl gene locus on the normal chromosome #9, while the aberrant c-abl related transcript in Ph+ CML derives from the hybrid bcr-abl gene formed as a result of the t(9;22). We further demonstrate that trisomy 8 in some instances is associated with enhanced expression of the c-myc oncogene.

Author List

Blick M, Romero P, Talpaz M, Kurzrock R, Shtalrid M, Andersson B, Trujillo J, Beran M, Gutterman J

Author

Razelle Kurzrock MD Center Associate Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blast Crisis
Cell Line
Chromosome Aberrations
Gene Expression Regulation
Humans
Karyotyping
Leukemia, Myeloid
Nucleic Acid Hybridization
Proto-Oncogenes