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Hyperventilation and Respiratory Alkalosis After Olanzapine for Insomnia: A Case Report. A A Pract 2021 Oct 20;15(10):e01535

Date

10/22/2021

Pubmed ID

34673660

DOI

10.1213/XAA.0000000000001535

Scopus ID

2-s2.0-85120541072 (requires institutional sign-in at Scopus site)

Abstract

Olanzapine is increasingly used as a sleep aid in hospitalized patients. Although thought to have less extrapyramidal effects, known side effects include oversedation, arrythmias, and hypotension. We present the unusual case of hyperventilation with respiratory alkalosis after the administration of olanzapine for insomnia in an elderly postoperative patient. This led to a second admission to the intensive care unit with invasive interventions including mechanical ventilation and vasopressor support. Caution must be exercised in prescribing antipsychotics for off-label use, especially in a population whose baseline characteristics can affect the pharmacokinetics of second-generation antipsychotics.

Author List

Hang D, Iqbal Z, Dolinski SY

Authors

Sylvia Dolinski MD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin
Dustin Hang MD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Alkalosis, Respiratory
Antipsychotic Agents
Humans
Hyperventilation
Sleep Initiation and Maintenance Disorders