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Interleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host disease. Biol Blood Marrow Transplant 2010 Jan;16(1):123-8

Date

09/24/2009

Pubmed ID

19772944

Pubmed Central ID

PMC2804961

DOI

10.1016/j.bbmt.2009.09.008

Scopus ID

2-s2.0-72649088089   14 Citations

Abstract

The transition from acute to chronic graft-versus-host disease (aGVHD, cGVHD) is characterized by the progressive loss of self-tolerance and the development of autoimmune manifestations. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been shown to play a prominent role in autoimmune disorders in the nontransplant setting, but the extent to which IL-17 is necessary for the autoimmunity that occurs as a consequence of GVHD is not known. In this study, we demonstrate using a combination of antibody-based and genetic approaches that IL-17 is not required for the loss of self-tolerance and resulting CD4(+)T cell-dependent pathologic damage that occurs during the evolution from aGVHD to cGVHD. Rather, T(H)1 cells and other proinflammatory cytokines are fully competent to promote autoimmune-mediated tissue damage. Thus, the selective targeting of IL-17 may not be a viable clinical strategy for preventing the autoimmune manifestations that develop during cGVHD.

Author List

Chen X, Das R, Komorowski R, van Snick J, Uyttenhove C, Drobyski WR

Authors

Xiao Chen MD, PhD Associate Professor in the Medicine department at Medical College of Wisconsin
William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Autoimmune Diseases
Bone Marrow Transplantation
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Chimera
Chronic Disease
Colon
Cytokines
Disease Progression
Flow Cytometry
Graft vs Host Disease
Interleukin-17
Lymphocytes
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mucous Membrane
Organ Specificity
Signal Transduction