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Myoelectric activity and absorptive capacity of rat small intestinal isografts. Dig Dis Sci 1996 Jun;41(6):1082-7

Date

06/01/1996

Pubmed ID

8654138

DOI

10.1007/BF02088223

Scopus ID

2-s2.0-0029679913   4 Citations

Abstract

The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 +/- 0.3/hr in controls and 1.8 +/- 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 +/- 1.3/hr in controls and 3.2 +/- 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 +/- 3% of the time in controls and 59 +/- 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 +/- 6 cm for controls and 51 +/- 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.

Author List

Telford GL, Nemeth MA, Sarna SK, Harris MS, Ramaswamy K, Schraut WH, Lee KK, Johnson CP, Walgenbach-Telford S

Author

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Digestion
Intestinal Absorption
Intestine, Small
Myoelectric Complex, Migrating
Rats
Rats, Inbred Lew
Sucrase
Transplantation, Isogeneic
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00