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VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells. FEBS Lett 2007 Oct 02;581(24):4681-4

Date

09/14/2007

Pubmed ID

17850794

DOI

10.1016/j.febslet.2007.08.063

Scopus ID

2-s2.0-34548791742 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

It is known that c-kit(+) cells are increased in heart after infarction. The exact origins of the cardiac c-kit(+) cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit(+) cells. Our data show that the number of c-kit(+) cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway.

Author List

Bai X, Sadat S, Gehmert S, Alt E, Song YH

Author

Xiaowen Bai PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adipose Tissue
Biomarkers
Cell Differentiation
Cells, Cultured
Humans
Proto-Oncogene Proteins c-kit
Stem Cells
Vascular Endothelial Growth Factor Receptor-2